題目：基于中藥有效成分的靶标發現
主講人：寇俊萍教授
時間：2013年12月24日（星期二）10:00 am
地點：仙林校區B14-201
寇俊萍，博士，中西醫結合基礎（藥學），教授，博士生導師, 中國藥科大學中藥複方研究室副主任。國家自然科學基金醫學部中醫中藥學科同行評議專家，科技部國際科技合作計劃評價專家，教育部科技成果與獎勵評審專家，教育部新世紀優秀人才，南京市科技評審專家，中國實驗方劑學雜志副主任編委,江蘇省藥理學會理事。
學習、工作經曆
1989.9-1994.6，中國藥科大學，中藥藥理專業學士
1994.8-2000.6，中國藥科大學中藥複方研究室見習研究員
1996.9-2000.6，中國藥科大學，中藥學專業在職碩士, 導師嚴永清教授
2000.6-2005.6，中國藥科大學，助理研究員
2001.9-2005.6，南京大學，生理學專業在職博士, 導師徐強教授
2005.6-2009.6，中國藥科大學，副研究員(破格晉升)
2006.10 中國藥科大學，中西醫結合基礎（藥學）碩士生導師
2007.10-2008.10，日本岐阜藥科大學，訪問學者
2009.6-，中國藥科大學，教授(破格晉升)
2011.7- 中國藥科大學，中西醫結合基礎（藥學）博士生導師
近期代表性論文及成果等
已發表論文108篇，其中通訊作者24篇，第1作者30篇，SCI收錄34篇；已獲授權專利17項，公開5項，主要代表性論文：
[1]Ruscogenin reducescerebral ischemic injury via NF-κB-mediated inflammatory pathway in the mousemodel of experimental stroke. Eur JPharmacol. 2013;714(1-3):303-311
[2]Diosgenindown-regulates NF-κB p65/p50 and p38MAPK pathways and attenuates acute lunginjury induced by lipopolysaccharide in mice. IntImmunopharmacol. 2013,15(2):240-245
[3]Chemical and microbial semi-synthesis oftetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity. Bioorg& Med Chem, 2013,21(1):62–69
[4]Diosgenin ameliorates palmitate- inducedendothelial dysfunction and insulin resistance via blocking IKKb and IRS-1 pathways. Atherosclerosis,2012,223(2): 350-358
[5]Safety evaluation of steroidal saponin DT-13isolated from the tuber of Liriope muscari (Decne.) Baily. Food ChemToxicol 2011, 49 (9): 2243-2251.
[6]Ginsenoside Rg1 protects against hydrogenperoxide-induced cell death in PC12 cells via inhibiting NF-kB activation. Neurochem Int 2011,58(1):119-125
[7]Ruscogenin mainly inhibits nuclear factor-κBbut not Akt and mitogen-activated protein kinase signaling pathways in humanumbilical vein endothelial cells. J Pharmacol Sci 2010,113(4),409 – 413
[8]Hypothesis on the principle of Danggui-Shaoyao-San (DSS) for treating different diseases via the histamine H1 Receptorpathway. Modern Tradit Chin Med Mater Med, 2010, 12(3): 325–330
[9]The effects of twelve representative?avonoids on tissue factor expression in human monocytes: Structure-activityrelationships. Thromb Res. 2009, 124(6): 714–720.
[10]Neuroprotectiveeffects of the aqueous extract of Chinese medicine Danggui-Shaoyao -san on agedmice. J Ethnopharmacol. 2005, 97:313-318.
[11]Inhibitoryeffect of ethanol extract from Radix Ophiopogonis japonicus on venous thrombosislinked with its endothelium-protective and anti-adhesive activities. VascPharmacol. 2005, 43 (3): 157 – 163.
