王令充

發布者:石喬梓發布時間:2024-07-18浏覽次數:2444


職稱:副研究員   E-mail:993wlc@njucm.edu.cn    主要研究方向:中藥活性大分子結構與功能

 

個人簡介

畢業于中國海洋大學,獲得理學博士學位,曾在香港大學中醫bevictor伟德官网訪問學者。研究重點集中在生物大分子與中藥多糖成分結構與功能研究領域,擅長多糖大分子的結構分析及産物表征技術,涉及功能性食品與口服給藥系統研發方面。迄今為止以第一或通訊作者共發表SCI論文30餘篇(>5.012篇,單篇最高影響因子11.13,總影響因子合計超過120,他引次數超1000次),發表中文核心論文約60餘篇,授權發明專利6項,主持或參與國家自然科學基金等系列項目6項,主持承擔或參與橫向合作項目10項,參與國家公益行業項目4項,獲得國家海洋科技成果2等獎項1項。國家自然科學基金函評專家,Frontiers of Pharmacology的評閱編委,ElsevierWiley數據庫20餘種SCI刊物的認定審稿專家。

 

承擔的主要科研項目

(1) 國家自然科學基金青年項目30900293,四角蛤蜊粘多糖的結構解析和材料學特性研究,2010/01-2012/12,主持,21

(2) 江蘇省高等學校自然科學研究重大項目(18KJA360008)蛤蜊多糖調控ROS介導肝細胞凋亡的核心糖鍊及構效,主持,2018/09-2021/0830

(3) 國家公益性行業科研專項(201205022-8),五種藥源生物活性物質的制備和産業化關鍵技術研究,參于,2012/01-2017/1268

(4) 國家公益性行業科研專項(201305007),江蘇沿海低值貝類全值化綜合利用關鍵技術開發與規模化示範,參于,2013/01-2018/121968

(5) 江蘇省中醫藥管理局科研項目(Lz09023),四角蛤蜊活性肽研究,主持,2010/01-2011/123

(6) 現代中藥制劑教育部重點實驗室開放基金(TCM2020-03),幾種高附加值海洋天然産物規模生産關鍵技術研究與示範,參于,2020/07-2021/124

(7) 校企橫向合作項目,“蘇峽”黃精藥材專屬标準建立及相關大健康産品開發,主持,2021/12-2023/12210

(8) 校企橫向合作項目,中藥複方“全真一氣湯”多糖的提取工藝優化與初步化學分析,主持,2021/09-2022/1210

(9) 艾蘭得研發中心科技孵化項目,可改善機體疲勞的黃精多糖固體飲料的研制,主持,2021/03-2022/0310

(10) 校企橫向合作項目,複方關節注射劑治療退行性關節炎功效預評價, 主持,2016/09-2017/129

 

代表性論文

(1) Zhou Bingqian; Zhang Wen; Wu Yujia; Yang Ying; Wang Na; Li Junsong; Fu Tingming; Wang Lingchong; Di Liuqing; Improved efficacy of Panax notoginseng saponin loaded into BSP/alginate microspheres for the treatment of alcoholic gastric ulcers, International Journal of Pharmaceutics, 2021, 596.     (期刊論文)

(2) Ying Yang#; Jing Ji#; Liuqing Di; Junsong Li; Lihong Hu; Hongzhi Qiao; Lingchong Wang*; Yibin Feng*; Resource, chemical structure and activity of natural polysaccharides against alcoholic liver damages, Carbohydrate Polymers, 2020, 2020(241): 116355.     (期刊論文)

(3) Lingchong Wang#; Ying Yang#; Hor-Yue Tan; Sha Li; Yibin Feng*; Protective Actions of Acidic Hydrolysates of Polysaccharide Extracted From Mactra veneriformis Against Chemical-Induced Acute Liver Damage, Front. Pharmacol.,, 2020, 11(446): 00446.     (期刊論文)

(4) Wu, Yujia#; Zhang, Wen#; Huang, Jianyu; Luo, Zichen; Li, Junsong; Wang, Lingchong*; Di, Liuqing*; Mucoadhesive improvement of alginate microspheres as potential gastroretentive delivery carrier by blending with Bletilla striata polysaccharide, International Journal of Biological Macromolecules, 2019,  doi.org/10.1016/(j.ijbiomac.2019.11.1): X1-11.     (期刊論文)

(5) Lingchong Wang#; Yujia Wu#; Junsong Li; Hongzhi Qiao; Liuqing Di*; Rheological and mucoadhesive properties of polysaccharide from Bletilla striata with potential use in pharmaceutics as bio-adhesive excipient, International Journal of Biological Macromolecules, 2018, 120(A): 529-536.     (期刊論文)

(6) Ling Chong Wang*; Liu Qing Di; Jun Song Li; Li Hong Hu; Jian Ming Cheng; Hao Wu; Elaboration in type, primary structure, and bioactivity of polysaccharides derived from mollusks, Critical Reviews in Food Science and Nutrition, 2019, 59(7): 1091-1114.     (期刊論文)

(7) Lingchong Wang*; Liye Chen; Junsong Li; Liqing Di; Hao Wu; Structural elucidation and immune-enhancing activity of peculiar polysaccharides fractioned from marine clam Meretrix meretrix (Linnaeus), Carbohydrate Polymers, 2018, 201: 500-513.     (期刊論文)

(8) Wang, Ling Chong; Zhang, Kun; Di, Liu Qing; Liu, Rui; Wu, Hao*; Isolation and structural elucidation of novel homogenous polysaccharide from Mactra veneriformis, Carbohydrate Polymers, 2011, 86(2): 982-987.     (期刊論文)

(9) Wang, Ling Chong*; Wu, Hao*; Ji, Jing; Xue, Feng; Liu, Rui; Preparation, analysis and antioxidant evaluation of the controlled product of polysaccharide from Mactra veneriformis by mild acid hydrolysis, Carbohydrate Polymers, 2016, 137(1): 709-718.     (期刊論文)

(10) Wang, Lingchong; Di, Liuqing; Liu, Rui; Wu, hao*; Characterizations and microsphere formulation of polysaccharide from the marine clam (Mactra veneriformis), Carbohydrate Polymers, 2013, 92(1): 106-113.     (期刊論文)

 

獲得獎項與榮譽

(1) 四角蛤蜊深加工綜合利用及功能性保健品的研究開發, 12年海洋科技成果二等獎(第3完成人),證書編号:HK2012-G-2-B57-03

 

其他成果

(1) Wang, Lingchong*; Wang, Xiangyu; Wu, Hao; Liu, Rui; Overview on Biological Activities and Molecular Characteristics of Sulfated Polysaccharides from Marine Green Algae in Recent Years, MARINE DRUGS, MDPI AG, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND, 4984-5020, 2014-09.     (書籍章節)

(2) 王令充,李俊松,狄留慶,楊穎,嵇晶. 一種抗酒精性肝損傷的白術多糖及其制備方法與應用[P]. CN113185618A2022-06-11.     (授權專利)

(3) 狄留慶,王令充,張雯,周冰倩. 三七白及pH響應性原位凝膠及其制備方法與應用[P]. CN113694144A,2021-11-26.     (專利公開)

(4) 吳皓,王令充,狄留慶,常念,程建明,文紅梅. 四角蛤蜊提取物及其制備方法和應用[P]. CN101548989B,2012-01-11.     (授權專利)

 




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