顔建明

姓名：顔建明 

職稱：教授

E-mail：jmyan@njucm.edu.cn                                                                                  

主要研究方向：藥物化學、藥物合成綠色方法、流動化學輔助的自動化藥物合成工藝

個人簡介

顔建明，江蘇省特聘教授，博士生導師。本科和碩士分别畢業于中國藥科大學和中國科學院上海藥物研究所（導師，胡立宏教授）。2017年博士畢業于新加坡南洋理工大學（導師，Naohiko Yoshikai），後在新加坡國立大學從事博士後工作（合作導師，吳傑教授），2023年進入bevictor伟德官网工作。曾作為主要研發人員參與制藥企業合作項目：停流微管技術在化學合成中的應用（GSK）、新型連續流裝置的輔助下開發氟化反應（Pfizer）。目前已在Nature Communications, J. Am. Chem. Soc., ACS Catalysis, Nature Chemistry等高水平期刊發表論文12篇。

承擔的主要科研項目

1.   江蘇省特聘教授支持計劃，主持，100萬

2.   江蘇省自然科學基金青年基金，20萬

3.    bevictor伟德官网高層次人才引進科研啟動項目，主持，100萬

代表性論文

1.     Jianming Yan, Haidi Tang, Xiangcheng Shi, Eugene Jun Rong Kuek, Chenguang Liu, Muliang Zhang, Jared L. Piper, Shengquan Duan, Jie Wu. Divergent Functionalization of Aldehydes Photocatalyzed by Neutral Eosin Y with Sulfone Reagents. Nature Communications. 2021, 12. 7214. (IF 14.9, 1區, 2021-Top 25Chemistry and Materials Sciences Articles in Nature Communications)DOI: 10.1038/s41467-021-27550-8

2.     Jianming Yan, Han Wen Cheo, Wei Kiat Teo, Xiangcheng Shi, Hui Wu, Shabana Binte Idres, Lih-Wen Deng, Jie Wu. A Radical Smiles Rearrangement Promoted by Neutral Eosin Y as a Direct Hydrogen Atom Transfer Photocatalyst. J. Am. Chem. Soc. 2020, 142, 11357–11362. (IF 14.6, 1區).https://pubs.acs.org/doi/10.1021/jacs.0c02052

3.     Jianming Yan,Md. Shafiqur Rahman, Naohiko Yoshikai Pd-Catalyzed Annulation of 1-Halo-8-arylnaphthalenes and Alkynes Leading to Heptagon-Embedded Aromatic Systems. Chemistry – A European Journal 2019, 25, 9395–9399. (IF 4.9, 2區).10.1002/chem.201805746

4.     Jianming Yan, Naohiko Yoshikai. Phenanthrene Synthesis via Chromium-Catalyzed Annulation of 2-Biaryl Grignard Reagents and Alkynes.Org. Lett. 2017, 19, 6630–6633. (IF 6.6,1區).DOI: 10.1021/acs.orglett.7b03342

5.     Jianming Yan, Naohiko Yoshikai. Chromium-Catalyzed Migratory Arylmagnesiation of Unactivated Alkynes. Org. Chem. Front.2017, 4, 1972–1975. (IF 5.1, 1區). DOI: 10.1039/C7QO00427C

6.     Jianming Yan, Naohiko Yoshikai. Cobalt-Catalyzed Arylative Cyclization of Acetylenic Esters and Ketones with Arylzinc Reagents through 1,4-Cobalt Migration. ACS Catal.2016, 6, 3738–3742. (IF 12.2, 1區). DOI: 10.1021/acscatal.6b01039

7.     Jianming Yan, Guan Liang Tay, Cuien Neo, Bo Ra Lee, and Philip Wai Hong Chan. Gold-Catalyzed Cycloisomerization and Diels–Alder Reaction of 1,6-Diyne Esters with Alkenes and Diazenes to Hydronaphthalenes and –cinnolines. Org. Lett.2015, 17, 4176–4179. (IF 6.6；1區). DOI:10.1021/acs.orglett.5b01935

8.     Zhiyuan Zhu, Jianming Yan, Wei Jiang, Xin-gang Yao, Jing Chen, Lili Chen, Chenjing Li, Lihong Hu, Hualiang Jiang, Xu Shen. Arctigenin Effectively Ameliorates Memory Impairment in AD Model Mice Targeting both Aβ Production and Clearance. J. Neurosci. 2013, 33, 13138–13149. (IF 5.9；1區). DOI: 10.1523/JNEUROSCI.4790-12.2013

9.     Xingyu Xu, Chong Li, Min Lei, Zhiyuan Zhu, Jianming Yan, Xu Shen, Lihong Hu. Synthesis and Decreasing Aβ Content Evaluation of Arctigenin-4-yl Carbamate Derivatives. Bioorg. Med. Chem. Lett.2016, 26, 2988–2991. (IF 2.5；3區). DOI: 10.1016/j.bmcl.2016.05.028.

10.  Xuanzi Fan , Muliang Zhang , Qi Zhou , Yanbin Zhang , Yuanjun Gao , Jiajia Yu , Wengang Xu , Jianming Yan , Haiwang Liu , Zhexuan Lei , Yan Chong Ter , Supphachok Chanmungkalakul , YanweiLum, Xiaogang Liu, Ganglong Cui, Jie Wu. Stepwise On-Demand Functionalization of Multihydrosilanes Enabled by Eosin Y-Based Hydrogen Atom Transfer Photocatalysis. 2023,NatureChemistry (https://doi.org/10.1038/s41557-023-01155-8).