姓名：康安
職稱：副教授
E-mail：kanga@njucm.edu.cn；13655182169
主要研究方向：天然藥物的體内代謝與分析；中藥防治胃腸道疾病的機理研究
個人簡介
博士、副教授、碩士生導師。2011年6月畢業于中國藥科大學，獲藥學（藥物代謝動力學）博士學位，同年9月來bevictor伟德官网工作。近年來主持國家自然科學基金2項、江蘇省自然科學基金1項，廳局級課題2項，國家重點實驗開放課題2項，校級課題3項，企業委托課題數項；以第一作者或通訊作者發表SCI論文22篇、中文核心期刊論文14篇，獲授權發明專利3項；獲江蘇省教育科學研究成果獎（高校自然科學類）三等獎（3/5）、中國中醫藥研究促進會科技進步獎三等獎（3/7）；為國家自然科學基金通訊評審專家、廣東省和浙江省自然科學基金通訊評審專家，江蘇省藥理學會中藥藥理專業委員會委員，《bevictor伟德官网學報》和《藥物評價研究》雜志青年編委。
承擔的主要科研項目
1. 國家自然科學基金面上項目，82374135 “芩連藥對”通過穩态調控腸道AHR-CYP1A/IL-22信号軸促潰瘍性結腸炎黏膜損傷修複的機制研究，2024.1-2027.12，49萬元
2. 國家自然科學基金項目青年基金，81202983，人參總皂苷胃腸道代謝處置差異表征及機制研究，2013.1-2015.12，23萬元
3. 江蘇省自然科學基金面上項目，BK20171491，基于AhR-CYP1A負反饋信号軸研究四君子湯調節腸黏膜免疫平衡機制，2017.07-2020.06，10萬元
4. 江蘇省中醫藥局科技項目，YB201809，參苓白術散調控短鍊脂肪酸合成代謝發揮腸黏膜屏障保護作用的機制研究，2018.07-2021.09，5萬元
5. 江蘇省高校自然科學基金，16KJB360005，基于短鍊脂肪酸合成調控的四君子湯抗腸黏膜炎機制研究，2016.08-2018.07，3萬元
6. 企業委托項目，石丹顆粒在慢性萎縮性胃炎大鼠體内效應物質發現及其活性成分對胃類器官增值和分化的影響，2023/8-2025/12，主持，14萬元
7. 企業委托項目，健腸1号方對IBS-D腸道5-HT影響及物質基礎研究，2022/11-2024/12，主持，15萬元
8. 企業委托項目，功能性消化不良大鼠模型建立與DLT藥效評價，2021/09-2023/12，主持，15萬元
代表性論文
1. Li Qin, Chen Zihan, Zhang Jianrong, Liu Li, Tang Dongxin, Li Liu, Zhang Jinge, Hu Cheng, Ma Jiayi, Cheng Haibo*, Kang An**, Sun Dongdong***. The colonic metabolism differences of main alkaloids innormal and colitis mice treated with Coptis chinensisFranch. and Sophora flavescens Ait. herbal pair using liquidchromatography-high resolution mass spectrometrymethod combined with chemometrics, Journal of Separation Science, 2023;46:2300094
2. Su Yan, Tao Lin, Zhang Xiaoli, Sheng Xianjie, Li qin, Fei Wenying, Yin tao, Kang An*, Aa Jiye**, Wang Guangji, Non-targeted characteristic filter analysis combined with in silico prediction strategies to identify the chemical components and in vivo metabolites of Dalitong Granules by UPLC-Q-TOF/MS/MS. Journal of Pharmaceutical and Biomedical Analysis, 2023; 222:115086
3. Song Mengmeng#, Xu Zhuicheng#, Han Sixuan, Sheng Xianjie, Chen Yan, Li Xinru, Su Yan, Li Qin, Shan Chenxiao, Xie Tong, Kang An*, Systematic Identification of the Main Constituents from Agrimonia pilosa Ledeb. and Their Metabolites in Rats using HPLC-Q-TOF-MS/MS, Planta Medical. 2022; 88: 1369–1383
4. Song Mengmeng#, Sheng Xianjie#, Zhang Jianrong, Li Xinru, Dai Qianyun, Chen Yan, Kang An*. Homeostatic regulation of the aryl hydrocarbon receptor-cytochrome P450 1a axis by Scutellaria baicalensis-Coptis chinensis herb pair and its main constituents. Journal of Ethnopharmacology, 2022; 297:115545.
5. Chen Yan#, Miao Zhiwei#, Sheng Xianjie, Li Xinru, Ma Jiayi, Xu Xiaomei, Li Hui**, Kang An*, Sesquiterpene lactones-rich fraction from Aucklandia lappa Decne. alleviates dextran sulfate sodium induced ulcerative colitis through co-regulating MAPK and Nrf2/Hmox-1 signaling pathway. Journal of Ethnopharmacology, 2022; 295:115401.
6. Kang An, Jiang Jialu, Li Qin, Sheng Xianjie, Chen Yan, Tan Jiani, Li Liu, Shen Weixing, Tang Dongxin, Cheng Haibo*, Sun Dongdong**, Characterization of the chemical constituents and in vivo metabolic profile of Scutellaria barbata D. Don by ultra high performance liquid chromatography with high-resolution mass spectrometry. Journal of Separation Science. 2022; 45(9):1600-1609.
7. Song Mengmeng, Sheng Xianjie, Ye Genyi, Xu Zhuicheng, Li Xinru, Xie Tong, Deng Haishan*, Kang An**, Selective enrichment of microbiota-derived tryptophan metabolites in mouse faeces based on molecularly imprinted solid-phase extraction for HPLC analysis. Journal of Pharmaceutical and Biomedical Analysis, 2022; 212:114641.
8. Tang Yuyin, Li Su, Hu Linyu, Sun Xuetong, Zhang Bei, Ji Wenwen, Ma Lijuan, Qian Wenhui, Kang An*, Zhu Dong**, Hybrid Poly(AMPS-CS)-Au Microneedle Arrays to Enrich Metabolites from Skin for Early Disease Diagnosis, Advanced Healthcare Materials, 2021; 10(19):e2100764.
9. Guo Sijia, Jiang Dongjing, Zhang Qiao, Zhang Yi, Yao Weifeng, Cao Yudan, Bao Beihua, Tang Yuping, Kang An*, Zhang Li*. Diverse role of gut microbiota on reduction of ascites and intestinal injury in malignant ascites effusion rats treated with Euphorbia kansui stir-fried with vinegar, Journal of Ethnopharmacology. 2021; 267:11348 9.
10. Kang An, Xie Tong, Zhu Dong, Shan Jinjun, Di Liuqing*, Zheng Xiao**, Suppressive Effect of Ginsenoside Rg3 against Lipopolysaccharide-Induced Depression-Like Behavior and Neuroinflammation in Mice, Journal of Agricultural and Food Chemistry, 2017; 65(32): 6861-6869.
獲得獎項與榮譽
1. 2020，第十二屆“挑戰杯”中國大學生創業計劃競賽銅獎，指導教師，
2. 2018江蘇省教育教學與研究成果獎（研究類）三等獎，3/5
其他成果
專利
1. 汪受傳，康安，單進軍，徐珊，狄留慶, 一種治療小兒腹瀉的中藥組合物及其制備方法和應用，ZL201510052111.1
教材
1. 藥物分析，中國中醫藥出版社，編委，2023
2. 儀器分析，科學出版社，編委，2019
