周桂生

發布者:石喬梓發布時間:2024-07-18浏覽次數:2190

職稱:副教授       E-mail:zhouguisheng1@126.com       主要研究方向:中藥藥效物質基礎和方藥配伍關系研究


 

個人簡介

2016年博士畢業于上海交通大學藥學專業。2022年入選江蘇省第333高層次人才層次培養對象。擔任Food ChemistryAnalytica Chimica ActaJournal of EthnopharmacologyFrontiers in PharmacologyMicrochemical Journal, Industrial Crops and Products等多本學術期刊的特邀審稿人。主持與重點參加國家及省部級課題10餘項。近年來,以第一/通訊作者發表學術論文30餘篇,SCI收錄25篇,h-index20。參與編寫專著1部。

 

承擔的主要科研項目

1. 國家自然基金面上項目,82074126,瀉心湯調控腸源性SCFAs介導腸上皮細胞-Th細胞交互應答改善T2DM腸上皮緊密連接的作用機制,2021.01-2024.1256萬元,參加

2. 國家自然基金面上項目,81973576,犀角地黃湯作用于急性腦出血p38MAPK信号通路的相須相使增效機制研究,2020.01-2023.1255萬元,參加

3. 國家自然基金青年項目,81803699,基于--腸道菌群軸的銀杏酮酯和多奈哌齊治療阿爾茨海默病聯用增效的作用機理研究,2019.01-2021.1221萬元,主持

4. 國家自然基金面上項目,81873001,基于VEGF-A通路中PLCγ1-PI3K/AKT反饋機制的蒲黃炭化瘀止血炮制機理研究,2019.01-2022.1257萬元,參加

5. 國家自然基金面上項目,81773882,當歸系列藥對在新生化顆粒中配伍作用的物質基礎和分子機制研究,2018.01-2021.1255萬元,參加

6. 江蘇省自然科學基金項目,BK20171068,基于--腸道菌群軸的銀杏酮酯配伍多奈哌齊抗阿爾茨海默病作用增強的機理研究,2017.07-2020.0720萬元,主持

7. 江蘇省自然科學基金項目,BK20171491,基于AHR-CYP1A負反饋信号研究四君子湯調節腸黏膜免疫平衡機制,2017.07-2020.0710萬元,參加

8. 國家自然基金面上項目,81673588,從代謝角度發現羅漢果皂苷抗肥胖型2型糖尿病物質基礎及作用機制,2017.01-2020.1262萬元,參加

9. 江蘇省中藥資源和産業化協同創新中心第三批重點立項項目,012092002006-4,銀杏落葉資源化利用和産業化研究,2016.10-2018.1230萬元,主持

10. 國家自然基金面上項目,81473318,四君子湯多糖的腸道菌群介導免疫作用發揮機制及物質基礎研究,2015.01-2018.1275萬元,參加

 

代表性論文

1. Gui-Sheng Zhou, Jiawei Lu, Tingting Xu, Yan Lu, Wenjun Chen, Jue Wang, Mengying Ke, Qiuxiang Shen, Youjuan Zhu, Jinjun Shan*, Shijia Liu*, Clinical Lipidomics Analysis Reveals Biomarkers of Lipid Peroxidation in Serum from Patients with Rheumatoid Arthritis, Microchemical Journal, 2021, 169, 106607.(第一作者)

2. Hui Yan, Zong-Jin Pu, Zhen-Yu Zhang, Gui-Sheng Zhou*, Dong-Qian Zou, Sheng Guo, Chao Li, Zhi-Lai Zhan, Jin-Ao Duan*, Research on Biomarkers of Different Growth Periods and Different Drying Processes of Citrus wilsonii Tanaka Based on Plant Metabolomics, Frontiers in Plant Science, 2021, 12, 700367.(共同通訊作者)

3. Gui-Sheng Zhou*, Yichu Yuan, You Yin*, Yuping Tang, Renjie Xu, Yan Liu, Peidong Chen, Lian Yin, Jin-Ao Duan*, Hydrophilic Interaction Chromatography Combined with Ultrasound-assisted Ionic Liquid Dispersive Liquid–liquid Microextraction for Determination of Underivatized Neurotransmitters in Dementia Patients’ Urine Samples, Analytica Chimica Acta, 2020, 1107, 74-84.(第一作者)

4. Jing Zhang, Jun Wang, Gui-Sheng Zhou*, Yajie Tan, Huijuan Tao, Jiaqian Chen, Zongjin Pu, Jiayan Ma, Wen She, An Kang, Yue Zhu, Pei Liu, Zhenhua Zhu, Xu-Qin Shi, Yuping Tang*, Jin-Ao Duan, Studies of the Anti-amnesic Effects and Mechanisms of Single and Combined Use of Donepezil and Ginkgo Ketoester Tablet on Scopolamine-induced Memory Impairment in Mice, Oxidative Medicine and Cellular Longevity, 2019, 8636835.(共同通訊作者)

5. 張靜, 史旭芹, 周桂生*, 譚亞傑, 陳嘉倩, 陶慧娟, 濮宗進, 劉培, 朱悅, 錢大玮, 唐于平*, 段金廒, 基于主成分分析和多指标綜合指數法對銀杏酮酯-多奈哌齊不同量比抗癡呆作用比較研究. 藥學學報, 2019, 54, 660669.(共同通訊作者)

6. Gui-Sheng Zhou, Yulong Zhang, Yang Li, Mengyue Wang, Xiaobo Li*, The Metabolism of a Natural Product Mogroside V, in Normal and Type 2 Diabetic Rats, Journal of Chromatography B, 2018, 1079, 25-33.(第一作者)

7. Gui-Sheng Zhou, Ying Peng, Lijuan Zhao, Mengyue Wang, Xiaobo Li*, Biotransformation of Total Saponins in Siraitia Fructus by Human Intestinal Microbiota of Normal and Type 2 Diabetic Patients: Comprehensive Metabolite Identification and Metabolic Profile Elucidation Using LC-Q-TOF/MS, Journal of Agricultural and Food Chemistry, 2017, 65, 1518-1524.(第一作者)

8. Gui-Sheng Zhou, Mengyue Wang, Yang Li, Renjie Xu, Xiaobo Li*, Comprehensive Qualitative and Quantitative Analysis on 61 Characteristic Constituents from Siraitia Grosvenorii Using a Rapid and Sensitive Ultrahigh-pressure Liquid Chromatography with Time-of-ight Mass Spectrometry, Journal of Pharmaceutical and Biomedical Analysis, 2016, 125: 1-14.(第一作者)

9. Gui-Sheng Zhou, Lei Fu, Xiaobo Li*, Optimisation of Ultrasound-assisted Extraction Conditions for Maximal Recovery of Active Monacolins and Removal of Toxic Citrinin from Red Yeast Rice by a Full Factorial Design Coupled with Response Surface Methodology, Food Chemistry, 2015, 170: 186-192.(第一作者)

10. Gui-Sheng Zhou, Xin Yao, Yuping Tang*, Dawei Qian, Shulan Su, Li Zhang, Chun Jin, Yong Qin, Jin-ao Duan*, An Optimized Ultrasound-assisted Extraction and Simultaneous Quantification of 26 Characteristic Components with Four Structure Types in Functional Foods from Ginkgo Seeds, Food Chemistry, 2014, 158: 177-185.(第一作者)

 

其他成果

論著:《藥對現代研究》編委




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