職稱:副教授 E-mail:zhangyue035@njucm.edu.cn 主要研究方向:核酸探針的開發設計及其在中藥快速鑒定中的應用
個人簡介
2020年博士畢業于南京大學,2021年入選江蘇省“雙創博士”人才計劃,在J. Am. Chem. Soc.、Angew. Chem.等國際一流期刊發表文章10餘篇。主持國家自然科學基金項目1項,江蘇省自然科學基金項目1項,國家重點實驗室開放基金1項。
承擔的主要科研項目
國家自然科學基金青年項目(22104063),通用型DNA納米衛星平台的構建及其在疾病診療的應用,2022/01-2024/12,主持,30萬
江蘇省自然科學基金青年項目(SBK2021042488),DNA納米線團的設計及其在腫瘤成像和治療中的應用,2021/07-2024/06,主持,20萬
南京大學生命分析化學國家重點實驗室開放課題(SKLACLS2109),金-DNA納米複合體應用于中藥活性分子的負載與釋放監控,2021/04-2022/12,主持,5萬
代表性論文
[1] Yue Zhang#, Weiwei Chen#, Yanyun Fang, Xiaobo Zhang, Ying Liu*, Huangxian Ju*. Activating a DNA Nanomachine via Computation across Cancer Cell Membranes for Precise Therapy of Solid Tumors. Journal of the American Chemical Society 143 (2021) 15233-15242. (IF: 14.6950).
[2] Yue Zhang, Xiaobo Zhang, Yuling He, Ying Liu*, Huangxian Ju*. Self-assembled micelle responsive to quick NIR light irradiation for fast drug release and highly efficient cancer therapy. Journal of Controlled Release 336 (2021) 469-479. (IF: 7.901).
[3] Yue Zhang#, Weiwei Chen#, Yue Zhang, Xiaobo Zhang, Ying Liu*, Huangxian Ju*. A near-infrared photo-switched microRNA amplifier for precise photodynamic therapy of early-stage cancers. Angewandte Chemie-International Edition 59 (2020) 21454-21459. (IF: 12.257).
[4] Yue Zhang, Yue Zhang, Guobin Song, Yuling He, Xiaobo Zhang, Ying Liu*, Huangxian Ju*. A DNA-azobenzene nanopump fueled by upconversion luminescence for controllable intracellular drug release. Angewandte Chemie-International Edition 58 (2019) 18207-18211. (IF: 12.257).
[5] Yue Zhang, Kewei Ren, Xiaobo Zhang, Zhicong Chao, Yuqin Yang, Deju Ye, Zhihui Dai, Ying Liu*, Huangxian Ju*. Photo-tearable tape close-wrapped upconversion nanocapsules for near-infrared modulated efficient siRNA delivery and therapy. Biomaterials 163 (2018) 55-66. (IF: 10.273).
[6] Kewei Ren#, Yue Zhang#, Xiaobo Zhang, Ying Liu*, Huangxian Ju*. In situ siRNA assembly in living cells for gene therapy with microRNA triggered cascade reactions templated by nucleic acids. ACS Nano 12 (2018), 10797-10806. (IF: 13.903).(共同第一作者)
獲得獎項與榮譽
2021年江蘇省“雙創博士”人才計劃