劉晶

發布者:石喬梓發布時間:2024-07-18浏覽次數:3544

職稱: 副主任藥師,副研究員                     E-mail: lygljhit@163.com                          

主要研究方向:心血管藥物作用機制研究;心肌細胞損傷标志物研究;micRNALncRNA在心肌細胞缺血再灌注損傷中的機制研究;線粒體動力學及線粒體自噬在心肌細胞損傷中的作用及機制研究;大黃酸對糖尿病心肌病的保護作用機制研究。

 

個人簡介

       心血管内科副主任藥師,副研究員,南京大學、南方醫科大學及bevictor伟德官网碩士生導師,現為江蘇省醫學會心血管分會基礎與臨床藥學組委員入選江蘇省第五期333工程第三層次培養對象近年以一作及通訊發表SCI論文十餘篇,申請國家級課題2江蘇省六大人才1項。

 

承擔的主要科研項目

1. 國家自然科學基金青年項目:mtDNA在糖尿病心肌細胞損傷中的作用及機制研究  項目批準号 81400238 2015.1-2017.12  23萬(第一負責人)

2. 國家自然科學基金面上項目:大黃酸對胰島β細胞Drp1-Pink1/Parki線粒體自噬通路的幹預作用研究 項目批準号:81773963 2018.01-2021.12 55萬(第一負責人)

3.大黃酸通過調節drp1誘導的線粒體自噬保護胰島β細胞作用機制研究。WSN-093 江蘇省六大人才項目 4萬 2019.1-2021.12(第一負責人)


代表性論文

1. Jing Liu, Zhaohong Chen, Yujing Zhang, Mingchao Zhang, Xiaodong Zhu, Yun Fan, Shaolin Shi, Ke Zen, Zhihong Liu* Rhein protects pancreatic β cells from Drp1-mediated mitochondria dysfunction under hyperglycemia. Diabetes. 2013 Nov;62(11):3927-35. DOI: 10.2337/db13-0251.IF8.3

2. Jing Liu, Ying Zou, Yi Tang, Mingming Xi, Liang Xie, Qigao Zhang, Jianbin Gong*. Circulating cell-free mitochondrial deoxyribonucleic acid is increased in coronary heart disease patients with diabetes mellitus.  J Diabetes Investig. 2016, 7(1): 109-14. DOI: 10.1111/jdi.12366.

3.  Liu JCai XXie LTang YCheng JWang JWang L*, Gong J*. Circulating Cell Free Mitochondrial DNA is a biomarker in the development of Coronary Heart Disease in the patients with type 2 diabetes. Clin Lab. 2015; 61(7):661-7. DOI: 10.7754/clin.lab.2014.141132.

4. Liu J, Zou Y, Tang Y, Xi M, Xie L, Zhang Q, Gong J. Circulating cell-free mitochondrial deoxyribonucleic acid is increased in coronary heart disease patients with diabetes mellitus[J]. J Diabetes Investig. 2016, 7(1): 109-114. DOI: 10.1111/jdi.12366.

5. Xie L, Liu S, Cheng J, Wang L, Liu J*, Gong J*. Exogenous administration of mitochondrial DNA promotes ischemia reperfusion injury via TLR9-p38 MAPK pathway[J]. Regul Toxicol Pharmacol, . 2017, 89:148-154. DOI:10.1016/j.yrtph.2017.07.028(共通訊)

6.   Zhang C, Tang Y, Li Y, Xie L, Zhuang W, Liu J*, Gong J*. Unfolded protein response plays a critical role in heart damage after myocardial ischemia/reperfusion in rats. PloS One. 2017, 12: e0179042. DOI:10.1371/journal.pone.0179042.(共通訊)

7. Chengcheng Zhang, Songqing He, Yanming Li, Feng Li, Zhengbing Liu, Jing Liu*, Jianbin Gon*. Bisoprolol protects myocardium cells against ischemia/reperfusion injury by attenuating unfolded protein response in rat. Sci Rep. 2017, 7(1): 11859. DOI: 10.1038/s41598-017-12366-8.

8. Jing Liu, Yanming Li, Yi Tang, Jinghua Cheng, Jing Wang, Jianhua Li, Xiaohua Ma, Wei Zhuang, Jianbin Gong*, Zhihong Liu* Rhein protects the myocardiac cells against hypoxia/reoxygention-induced injury by suppressing GSK3β activity. Phytomedicine. 51: 1-6.  DOI: 10.1016/j.phymed.2018.06.029.

9. Liang Xie, Songqing He, Na Kong, Ying Zhu, Yi Tang, Jianhua Li, Zhengbing Liu, Jing Liu*, Jianbin Gong*. Cpg-ODN, TLR9 Agonist,  Aggravates Myocardial Ischemia/ Reperfusion Injury by Activation of TLR9-P38 MAPK Signaling. Cell Physiol Biochem. 2018, 47(4): 1389-1398. DOI: 10.1159/000490828(共通訊)

10. Jing Wang, Jing Liu*, Liang Xie, Xiaomin Cai, Xiaohua Ma, Jianbin Gong* Bisoprolol, a β1 antagonist, protects myocardial cells from ischemia reperfusion injury via PI3K/AKT/GSK3β pathway. Fundam Clin Pharmacol. 2020, 34(6): 708-720. DOI: 10.1111/fcp.12562.

11. 姚道敏謝亮宮劍濱朱靜劉晶* 基于生物信息學方法分析心肌梗死大鼠miRNA芯片.《中國藥理學通報》 2021375673-680

12. 柳麗,季凱琳,徐海玲,曹夢怡,蘇丹,劉晶*. 雷公藤甲素對皮質酮誘導小鼠海馬神經元細胞損傷的保護作用. 醫學研究生學報. 2021;34(11):1138-1143

 




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