姓名:陳佩東
職稱:教授
E-mail:cpd@njucm.edu.cn
主要研究方向:中藥活性成分與中藥炮制機理研究。
個人簡介
陳佩東,男,教授,博士生導師。現執教于bevictor伟德官网中藥化學教研室,任教研室主任。主要從事中藥化學、天然藥物化學、波譜學等課程的教學,科研方向為中藥活性成分及複方配伍機理、中藥炮制和中藥的質量标準等領域的研究。主持了國家自然科學基金面上項目及其他各級各類課題4項,發表論文20餘篇,其中SCI 10餘篇。在參與完成的多項課題中,獲得多項獎項。
承擔的主要科研項目
1.國家自然科學基金面上項目(82374037),基于凝血級聯-VEGFA-Ang1/Tie2通路協同機制的蒲黃炭炮制機理及物質基礎研究(2024.1-2027.12),主持。
2.國家自然科學基金面上項目(81873001),基于VEGF-A通路PLCγ1-PI3K/Akt反饋機制的蒲黃炭化瘀止血炮制機理研究,2019/01-2022/12,主持。
3.國家自然科學基金面上項目(81573604),基于Na-K-ATP酶對津液“收斂固澀”探讨五味子“生熟異用”作用機制,2008/01-2010/12,參與。
3.國家自然科學基金青年項目(3701108),醋蒸五味子炮制機理的研究,2019/01-2022/12,參與。
4.中國藥典會項目(項目編号:YD-108),蒲黃炭飲片質量标準研究,2009/01-2010/12,主持。
5.江蘇省中醫院管理局項目,蒲黃炭炮制機理研究,2007/01-2010/12,主持。
6.bevictor伟德官网風險基金項目,抗潰瘍性結腸炎創新中藥新藥的研制(CX201202),2012/01-2014/12,主持。
代表性論文
1. Gao M, Lan J, Zha Y, Yao W, Bao B, Shan M, Zhang F, Zhou G, Yu S, Cheng F, Cao Y, Yan H, Zhang L*, Chen P*. Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Int J Biol Macromol. 2022,S0141-8130(22)02231-0. doi: 10.1016/j.ijbiomac.2022.10.002.
2. Gao M, Lan J, Zhang Y, Yu S, Bao B, Yao W, Cao Y, Shan M, Cheng F, Zhang L*, Chen P*. Discovery of processing-associated Q-marker of carbonized traditional Chinese medicine: An integrated strategy of metabolomics, systems pharmacology and in vivo high-throughput screening model. Phytomedicine. 202,102:154152. doi: 10.1016/j.phymed.2022.154152.
3. Wei X, Gao M, Sheng N, Yao W, Bao B, Cheng F, Cao Y, Yan H, Zhang L, Shan M*, Chen P*. Mechanism investigation of Shi-Xiao-San in treating blood stasis syndrome based on network pharmacology, molecular docking and in vitro/vivo pharmacological validation. J Ethnopharmacol. 2022,301:115746. doi: 10.1016/j.jep.2022.115746.
4.Gao M#, Ge Z, Deng R, Bao B, Yao W, Cao Y, Shan M, Cheng F, Yan H, Chen P*, Zhang L*. Evaluation of VEGF mediated pro-angiogenic and hemostatic effects and chemical marker investigation for Typhae Pollen and its processed product.J Ethnopharmacol. 2021,268:113591. doi: 10.1016/j.jep.2020.113591
5. Gao M#, Lan J, Bao B, Yao W, Cao Y, Shan M, Cheng F, Chen P*, Zhang L*. Effects of carbonized process on quality control, chemical composition and pharmacology of Typhae Pollen: A review. J Ethnopharmacol. 2021,270:113774. doi: 10.1016/j.jep.2020.113774.
6.Peidong Chen#, Yudan Cao, Beihua Bao, Li Zhang*, Anwei Ding.Antioxidant capacity of Typha angustifolia extracts and two active flavonoids,Pharm Biol. 2017 ,55(1):1283-1288. doi: 10.1080/13880209.2017.1300818..
7.Peidong Chen#, Shijia Liu#, Guoliang Dai, Liyan Xie, Jie Xu, Ling Zhou, Wenzheng Ju*, Anwei Ding. Determination of typhaneoside in rat plasma by liquid chromatography–tandem mass spectrometry, J Pharm Biomed Anal. 2012,70:636-9. doi: 10.1016/j.jpba.2012.06.032.
8.Liu S#, Dai G, Sun L, Sun B, Chen D, Zhu L, Wang Y, Zhang L, Chen P*, Zhou D*, Ju W*. Biotransformation and Metabolic Profile of Limonin in Rat Liver Microsomes, Bile, and Urine by High-Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry. J Agric Food Chem. 2018,66(40):10388-10393. doi: 10.1021/acs.jafc.8b02057.
9. Liu S#, Wang Y, Liu H, Xu T, Wang MJ, Lu J, Guo Y, Chen W, Ke M, Zhou G, Lu Y*, Chen P*, Zhou W*. Serum lipidomics reveals distinct metabolic profiles for asymptomatic hyperuricemic and gout patients. Rheumatology (Oxford). 2022,61(6):2644-2651. doi: 10.1093/rheumatology/keab743.
10.Peidong Chen#*, Xi Zhou, Li Zhang, Mingqiu Shan, Beihua Bao, Yudan Cao, An Kang, Anwei Ding. Anti-inflammatory effects of Huangqin Tang extract in mice on ulcerative colitis,J Ethnopharmacol. 2015,162:207-14. doi: 10.1016/j.jep.2014.12.039.
獲得獎項與榮譽
2019,江蘇中醫藥科學技術獎,代表性中藥炭藥炮制機理和質量标準研究,二等獎,江蘇中醫藥科學技術委員會,排名第四。
其他成果
專利:
1. 一種用黃蜀葵稭稈制備塑木材料的方法,ZL 2013 1 0494845.6,陳佩東,段金廒,嚴輝,發明專利。
2.一種新型真空潤藥機 ZL2018 2 0741140.8,陳佩東,包貝華,程芳芳,單鳴秋,張麗,于生,曹雨誕,姚衛峰,石海培,實用新型專利。
3.一種黃芩湯顆粒治療潰瘍性結腸炎及其制備方法,ZL2014 1 0287583.0,陳佩東,發明專利。
4.一種厚樸去粗皮的加工裝置,ZL 2015 2 0423481.7, 陳佩東,張麗,單鳴秋,包貝華,曹雨誕,丁安偉,實用新型專利。
教材:
天然藥物化學,副主編,中國醫藥科技出版社,2021.